Increased Attention Enhances Both Behavioral and Neuronal Performance

intracellular targeting of WR4017/pMGB2 led to expression of CS antigen on the cell surface in association with dass I MHC molecules and the induction of a cell-mediated immune response. This technique should be useful for precise mapping of critical T cell epitopes, and for construction of vaccines against other diseases in which cell-mediated immunity is important, such as leprosy, leishmaniasis, schistosomiasis, and infection with rickettsia or the human immunodeficiency virus. Mutants of S. tyhi have been used safely in humans as oral vaccines and elicit cellular immunity against S. typhi antigens (9, 16). Preliminary data indicate that galE (Ty21A) or aroA (541Ty) mutants of S. typhi, and S. typhimurium strain WR4017, express P. fiacaum antigens when transformed with plasmids containing the P. falkparum CS gene. Thus it may be possible to develop an orally administered vaccine for the prevention of malaria. thickness to within 0.10 mm was determined with Schnelltastr calipers by an observer blinded to immunization group and tst antigen. Mice immunized sc with WR4017/pMGB2 were not tested for DTH. 25. We thank H. Sidbery, C. Life, M. Gross, J. Egan, D. Gordon, I. Schneider, M. Dowier, U. Krzych, M. Chulay, and A. Shaferman.